 | Dr Winston Duo WU Research Fellow Office Ph: +61 3 9905 9344 Office Fax: 9905 5686 e-mail: winston.wu@monash.edu |
Education
· PhD of Chemical Engineering, Monash University, Australia
· Master of Biomedical Engineering, University of Melbourne, Australia
· Bachelor of Engineering, Central South University, China
· Diploma of Business Adminstration, Central South University, China
Key Research Projects
· Project: Design and fabrication of lab/pilot-scale spray dryers equipped with a novel nozzle used as the atomizer for synthesizing microparticle/composite with uniform characteristics
Funded by ARC Discovery Grant (DP0773688)
Duties:
- Trials on commercially available monodisperse droplet generators for potential application as the lab/pilot scale spray dryer atomizers
- Design and fabricate a novel monodisperse droplet generator
- Study fluid mechanics of droplet formation by the novel droplet generator
- Modify the current design of the lab/pilot scale spray dryers
Main Achievements:
- Successfully designed and fabricated two versions of droplet generators, referred to as type-I and II micro-fluidic aerosol nozzle (MFAN-I and -II)
- Successfully designed and fabricated two versions of spray dryers, referred to as type-I and II micro-fluidic-jet spray dryer (MFJSD-I and II)
- Verified the use of professional SLR digital camera with the special microlense and flash light to visualize droplet formation process
- Proposed the fluid mechanics of monodisperse droplet formation by the MFAN: effects of fluid properties, flow rate and disturbing frequency on droplet size and uniformity
- Synthesized lactose particles with controllable uniform size
- Verified the design of the MFAN and MFJSD
· Project: Synthesis of uniform silica microencapsulates via a novel spray route
Duties:
- Use MFJSD-I to produce the Vitamin B12-doped silica microencapsulates
- Investigate the effect of possible additives on particle size, morphology and drug release
- Investigate the effect of Vitamin B12-doped content on drug release profiles
- Study the release kinetics using various mathematical models
Main Achievements:
- Utilized the MFJSD-I to synthesize non-agglomerated and uniform Vitamin B12-doped silica microencapsulates
- Obtained SEM pictures of the spray-dried particles and compared different effects of additive lactose and alginate on the particle size and morphology
- Investigated effects of initial drug content, additive lactose and alginate on the in vitro drug release profiles using UV- Vis
- Evaluated drug release mechanisms by fitting the release data with mathematical models
· Project: Production of spray-dried mesoporous silica microparticles
Duties:
- Use MFJSD-I to produce mesoporous silica microparticles
- Study the water/TEOS molar ratio on the particle structure
- Investigate the effect of pH value of the precursor solution on the particle structure
- Elevate MFJSD-I production capacity of spray-dried product with low density
Main Achievements:
- Synthesized non-agglomerated and uniform mesoporous silica microparticles using the MFJSD-I
- Obtained SEM pictures of the spray-dried particles and evaluated effects of mass content and pH value on the particle size and morphology
- Obtained TEM pictures and particle specific area data and evaluated effects of the water/TEOS molar ratio and pH value on the particle pore structure and size
· Project: Assembly of Nano-sized Eu Oxide-doped, non-agglomerated and uniform photoluminecent microcomposites via spray drying and calcination
Duties:
- Use MFJSD-II to produce Eu-doped silica microcomposites
- Study the particle formation mechanisms and the effect of the presence of nano-silica colloidal sol on the spray-dried particle morphology
- Study the crystal form of spray dried samples before and after calcination
- Study the internal structure of spray dried samples before and after calcination
- Investigate the distribution of Eu element within the silica matrix
- Investigate the effect of spray drying and calcination conditions on the PL properties
Main Achievements:
- Synthesized non-agglomerated and uniform Eu-doped silica microcomposites using the MFJSD-II
- Obtained FESEM pictures of the spray-dried products and proposed the possible mechanisms of particle formation during spray drying process
- Performed XPS analysis on the spray-dried products and verified the homogeneous distribution of Eu element on the particle surface
- Conduced XRD to verify the amorphous structure of the spray-dried particles and identified crystal structure of the calcined samples
- Obtained FT-IR data of the spray-dried and calcined samples to indicate the formation of Eu-O-Si bond within the composite
- Obtained TEM pictures the calcined particles to confirm the formation and homogeneous distribution of nano-sized Eu oxides within the composite
- Conducted particle analysis using fluorescence spectroscopy and identified the specific PL property
- Evaluated the dependence of the relative PL intensity on the Eu-doped content and spray drying temperature
· Project: Synthesis of unifrom TiO2/silica photosensitive microcomposites via a novel spray route
Duties:
- Use MFJSD-II to produce unifrom TiO2/silica photosensitive microcomposites
- Study effect of different Ti resources on the pore structure of the spray-dried particles
- Investigate effect of different Ti/Si ratios on the pore structure of the spray-dried particles
- Compare effect of spray drying route with conventional sol-gel method on particle structure
Main Achievements:
- Synthesized TiO2/silica photosensitive microcomposites using the MFJSD-II
- Obtained SEM/TEM pictures of the spray-dried particles and evaluated the particle size, morphology and pore structure
Professional Honours & Awards
· Australia, The 2nd Victoria Chinese PhD and Young Scholars Research Workshop Victory, “Best Paper Award”, 2008
· Melbourne, Australia, “Australian Research Council (ARC) Discovery Scholarship”, 2007
· Australia, The 1st Victoria Chinese PhD and Young Scholars Research Workshop Victory, “Best Paper Award”, 2007
· Monash University, Australia, “International Student Scholarship”, 2006
· Hu’nan province, China, “Excellent Undergraduate Student”, 2005 (Top 5‰)
· Central South University, “Excellent Bachelor Thesis”, 2005 (Top 1‰)
· School of Metallurgical Science and Engineering, Central South University, the Qualification to Be Exempted from National Entrance Examination and Tuition for Postgraduate Education, 2004 (Top 1‰)
· Central South University, “ZHAO TIAN CONG” Scholarship, 2003 (Top 1‰)
· Central South University, Outstanding Student Scholarship, 2002, 2003 (Top 1%)
Other Honours & Awards
· Australia, Association of Victoria Chinese PhD and Young Scholars, President, 2010
· Australia, Association of Victoria Chinese PhD and Young Scholars, Vice President, 2009
· School of Metallurgical Science and Engineering, Central South University, President of Student Union, 2003, 2004
· Hu’nan province, China, Champion of Debate Competition of College Students, 2004
· Central South University, Champion of League Matches of Basketball Clubs, 2003, 2004
· Hu’nan province, China, the Excellent Student Leader, 2002, 2003
Research Publications
Journal Papers
Winston Duo Wu, Kamlesh C. Patel, Samuel Rogers and Xiao Dong Chen (2007) Monodisperse Droplet Generators as Potential Atomizers for Spray Drying Technology, Drying Technology, 25:1907-1916.
Samuel Rogers, Winston Duo Wu, Jonathan Saunders and Xiao Dong Chen (2007) Making Spray Freeze-dried Milk Powder in a Laboratory Scale Encapsulator, Drying Technology, 26:404-412.
Winston Duo Wu, Sean Xuqi Lin, and Xiao Dong Chen. Monodisperse Droplets Formation by Newly Designed Glass Nozzles, (2009), AIChE Journal. (In press)
Winston Duo Wu, Ria Amelia, Na Hao, Cordelia Selomulya, Dongyuan Zhao and Xiao Dong Chen. Assembly of Non-agglomerated Uniform Photoluminecent Microcomposites Using a Novel Micro-Fluidic-Jet-Spray-Dryer, (2010), AIChE Journal.
Winston Duo Wu, Sean Xuqi Lin, Cordelia Selomulya and Xiao Dong Chen. Synthesis of Uniform Silica Microencapsulates via a Novel Micro-Fluidic-Jet-Spray-Dryer: Effects of Additives on Particle Size, Morphology and In Vitro Drug Release, (2010), Chemical Engineering Journal. (Submitted)
Wen Jie Liu, Winston Duo Wu, Cordelia Selomulya and Xiao Dong Chen. Fabrication of Uniform Eudragit RS Based Microparticles as Drug Carriers by a Novel Spray Drying Technique (2010), International Journal of Pharmaceutics. (In preparation)
Wen Jie Liu, Winston Duo Wu, Cordelia Selomulya and Xiao Dong Chen. Self-assembly and Drug Release Characteristics of Eudragit NE Based Microparticles Produced by a Novel Spray Drying Technique (2010), International Journal of Pharmaceutics. (In preparation)
Samuel Rogers, Winston Duo Wu, Sean Xuqi Lin and Xiao Dong Chen. A Monodisperse Spray Dryer for Producing Milk Powder: Investigation of Particle Shrinkage and Puffing, (2010), Chemical Engineering Science. (In preparation)
Conference Papers
Kamlesh C. Patel, Winston Duo Wu and Xiao Dong Chen (2007) Review on Generation of Monodisperse Sprays for Manufacturing Micron-size Uniform Particles Using a Spray Drying Technique. The Proceedings of the 5th Asia-Pacific Drying Conference, Hongkong, China.
Winston Duo Wu, Samuel Rogers, Kamlesh C. Patel, Sean Xu Qi Lin, and Xiao Dong Chen (2007) Ink-jet-micro-fluidic-spray-drier for Making High Quality Micron/Nano-sized Bioactive Particles. The Proceedings of the 1st Victoria Chinese PhD and Young Scholars Research Workshop, Melbourne, Australia.
Winston Duo Wu, Sean Xu Qi Lin, and Xiao Dong Chen (2008) An Ink-jet Nozzle for Making Micron-sized Monodisperse Droplets. The Proceedings of the 2nd Victoria Chinese PhD and Young Scholars Research Workshop, Melbourne, Australia.
Winston Duo Wu, Sean Xu Qi Lin, Cordelia Selomulya, Na Hao, and Xiao Dong Chen, (2009) In Vitro Release of Vitamin B12 from Uniform Non-agglomerated Silica Microparticles Produced by a Novel Micro-Fluidic-Jet Spray dryer. The Proceedings of the 4th Nordic Drying Conference, Reykjavik, Iceland.
Ria Amelia, Winston Duo Wu, Cordelia Selomulya, Sean Lin and Xiao Dong Chen, (2010) Production of Microstructure of Europium Particles Embedded in Silica and Lactose Shell by Micro-Fluidic-Jet-Spray-Dryer. The Proceedings of 2010 International Conference on Nanoscience and Nanotechnology, Sydney, Australia.