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Michelle Ji Yeon Yoo
(PhD student)
tel: +61-3-99051482
e-mail: michelle.yoo eng.monash.edu.au
Office: Room 109, Building 37 |
In vitro digestion model simulating the human upper gastrointestinal tract.
In vitro digestion models simulating the human gastrointestinal tract (GIT) are extensively used in accomplishing the studies of pharmaceutics, pharmacology, nutraceutics, toxicology, bioaccessibility, bioavailability, micro-ecological and general safety assessments where the complexities of in vivo studies have evolved from ethical constraints, costs, accuracy, reproducibility of data, physiological differences among individuals and excessive time consumption. The competence and the safety of ingesting fortified and/or pre-/probiotic incorporated foods and drugs, genetically modified foods, as well as novel compounds at the pre-clinical (drug discovery) phase of the FDA approval process, cannot always be assured. Thus creating an in vitro digestion model which dissembles the human GIT with respect to its anatomy, functions, motility and physiology, will consent us to observe the dynamic processes as closely as possible.
Innovative concepts of delivering the gastric secretion and the peristaltic gastric motility are incorporated with sophisticated compositions of the secretions of the upper GIT in the artificial stomach reactor in which the generated samples are comprehensively analyzed and compared to in vivo and clinical data for validation.
Publications
Ji Yeon Yoo and Xiao Dong Chen (2006) GIT physicochemical modeling – A critical review. International Journal of Food Engineering 2 (4), article 4
Xiao Dong Chen and Ji Yeon Yoo (2006) Food engineering as an advancing branch of chemical engineering. International Journal of Food Engineering 2 (2), article 1.
Ji Yeon Yoo and Xiao Dong Chen (2006) GIT physiochemical modeling – critical review. Annual Australasian Conference of Chemical Engineering (Chemeca 2006), Food and Beverage, 210
Ji Yeon Yoo, Xiao Dong Chen, Ruben Mercadé-Prieto and Ian Wilson (2007) Dissolving heat-induced protein gel cubes in alkaline solutions under natural and forced convection conditions. Journal of Food Engineering 79, 1315-1321
Personal Interests
Dogs – my best furry friend, Toto.
Movies, Music & Books – watching movies, listening to music and reading books (non-fiction).
Driving a car, fishing, gardening and playing sudoku well describe my weekends.
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